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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEK2
All Species:
23.64
Human Site:
S400
Identified Species:
37.14
UniProt:
P51955
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51955
NP_002488.1
445
51763
S400
N
I
M
R
S
E
N
S
E
S
Q
L
T
S
K
Chimpanzee
Pan troglodytes
XP_514178
522
59597
S477
N
I
M
R
S
E
N
S
E
S
Q
L
T
S
K
Rhesus Macaque
Macaca mulatta
XP_001108740
445
51674
S400
N
V
M
R
S
E
N
S
E
S
Q
L
T
S
K
Dog
Lupus familis
XP_537144
668
75595
S623
N
V
M
R
S
K
N
S
E
S
L
L
T
S
K
Cat
Felis silvestris
Mouse
Mus musculus
O35942
443
51289
S399
N
T
A
R
S
E
N
S
E
S
Y
L
A
K
S
Rat
Rattus norvegicus
XP_001055166
443
51340
S399
N
T
T
R
S
E
N
S
E
S
Q
L
A
K
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509538
499
57433
V454
E
N
T
R
S
D
N
V
E
N
L
P
G
S
K
Chicken
Gallus gallus
NP_001026221
444
51581
V399
D
G
M
P
S
V
N
V
E
N
Y
P
L
S
K
Frog
Xenopus laevis
NP_001079490
442
52004
S392
H
V
H
F
G
S
N
S
K
E
N
R
S
S
D
Zebra Danio
Brachydanio rerio
Q90XC2
697
76523
G541
L
G
L
D
K
V
S
G
T
E
E
P
S
S
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572415
735
82962
R469
E
L
Q
L
A
E
Q
R
V
Q
T
L
E
R
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786794
453
51921
R367
Q
I
P
K
V
I
T
R
V
T
E
L
R
R
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9CAU7
606
68016
G554
Q
R
A
E
A
L
E
G
L
L
E
F
S
A
R
Baker's Yeast
Sacchar. cerevisiae
P22209
435
51185
Y362
F
E
R
K
L
L
D
Y
E
N
E
L
T
N
I
Red Bread Mold
Neurospora crassa
P48479
858
94329
E508
N
P
R
M
I
F
G
E
E
P
T
S
T
D
K
Conservation
Percent
Protein Identity:
100
85
98.4
62.5
N.A.
87.6
89.4
N.A.
69.7
77
73.9
25.8
N.A.
30.2
N.A.
N.A.
54.3
Protein Similarity:
100
85
99.3
65.4
N.A.
94.1
95
N.A.
80.9
88.7
86.7
39
N.A.
44.3
N.A.
N.A.
72.1
P-Site Identity:
100
100
93.3
80
N.A.
60
66.6
N.A.
40
40
20
6.6
N.A.
13.3
N.A.
N.A.
13.3
P-Site Similarity:
100
100
100
93.3
N.A.
60
66.6
N.A.
53.3
53.3
46.6
33.3
N.A.
33.3
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.2
22.7
24.3
Protein Similarity:
N.A.
N.A.
N.A.
44.8
43.8
36.1
P-Site Identity:
N.A.
N.A.
N.A.
0
20
26.6
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
53.3
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
14
0
14
0
0
0
0
0
0
0
14
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
7
0
7
7
0
0
0
0
0
0
7
7
% D
% Glu:
14
7
0
7
0
40
7
7
67
14
27
0
7
0
0
% E
% Phe:
7
0
0
7
0
7
0
0
0
0
0
7
0
0
7
% F
% Gly:
0
14
0
0
7
0
7
14
0
0
0
0
7
0
0
% G
% His:
7
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
20
0
0
7
7
0
0
0
0
0
0
0
0
7
% I
% Lys:
0
0
0
14
7
7
0
0
7
0
0
0
0
14
47
% K
% Leu:
7
7
7
7
7
14
0
0
7
7
14
60
7
0
0
% L
% Met:
0
0
34
7
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
47
7
0
0
0
0
60
0
0
20
7
0
0
7
0
% N
% Pro:
0
7
7
7
0
0
0
0
0
7
0
20
0
0
0
% P
% Gln:
14
0
7
0
0
0
7
0
0
7
27
0
0
0
14
% Q
% Arg:
0
7
14
47
0
0
0
14
0
0
0
7
7
14
7
% R
% Ser:
0
0
0
0
54
7
7
47
0
40
0
7
20
54
14
% S
% Thr:
0
14
14
0
0
0
7
0
7
7
14
0
40
0
0
% T
% Val:
0
20
0
0
7
14
0
14
14
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
7
0
0
14
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _